Ordering COVID-19 Vaccines for Social Welfare with Information Updating: Optimal Dynamic Order Policies and Vaccine Selection in the Digital Age

In the digital age, operations can be improved by a wise use of information and technological tools. During the COVID-19 pandemic, governments faced various vaccine choices having different efficacy and availability levels at different time points. In this paper, we consider a two-stage vaccine ordering problem of a government from a first and only supplier in the first stage, and either the same supplier or a new second supplier in the second stage. Between the two stages, potential demand information for the vaccine is collected to update the forecast. Using dynamic programming, we derive the government's optimal vaccine ordering policy. We find that the government should select its vaccine supplier based on the disease's infection rate in the society. When the infection rate is low, the government should order nothing at the first stage and order from the supplier with a higher efficacy level at the second stage. When the disease's infection rate is high, the government should order vaccines at the first stage and switch to the other supplier with a lower efficacy level at the second stage. We extend our model to examine (i) the value of blockchain adoption and (ii) the impact of vaccines' side effects. [ FROM AUTHOR] Copyright of IISE Transactions is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Reforming global supply chain management under pandemics: The GREAT‐3Rs framework

The recent outbreak of Coronavirus disease 2019 (COVID‐19) has posed serious threats and challenges to global supply chain management (GSCM). To survive the crisis, it is critical to rethink the proper setting of global supply chains and reform many related operational strategies. We hence attempt to reform the GSCM from both supply and demand sides considering different pandemic stages (i.e., pre, during, and post‐pandemic stages). In this research paper, we combine a careful literature review with real‐world case studies to examine the impacts and specific challenges brought by the pandemic to global supply chains. We first classify the related literature from the demand and supply sides. Based on the insights obtained, we search publicly available information and report real practices of GSCM under COVID‐19 in nine top global enterprises. To achieve responsiveness, resilience, and restoration (3Rs), we then propose the "GREAT‐3Rs” framework, which shows the critical issues and measures for reforming GSCM under the three pandemic stages. In particular, the "GREAT” part of the framework includes five critical domains, namely, "government proactive policies and measures,” "redesigning global supply chains,” "economic and financing strategies under risk,” "adjustment of operations,” and "technology adoption,” to help global enterprises to survive the pandemic;"3Rs” are the outputs that can be achieved after using the "GREAT” strategies under the three pandemic stages. Finally, we establish a future research agenda from five aspects.

Baicalein self-microemulsion based on drug-phospholipid complex for the alleviation of cytokine storm.

Cytokine storm is a phenomenon whereby the overreaction of the human immune system leads to the release of inflammatory cytokines, which can lead to multiple organ dysfunction syndrome. At present, the existing drugs for the treatment of cytokine storm have limited efficacy and severe adverse effects. Here, we report a lymphatic targeting self-microemulsifying drug delivery system containing baicalein to effectively inhibit cytokine storm. Baicalein self-microemulsion with phospholipid complex as an intermediate carrier (BAPC-SME) prepared in this study could be spontaneously emulsified to form 12-nm oil-in-water nanoemulsion after administration. And then BAPC-SME underwent uptake by enterocyte through endocytosis mediated by lipid valve and clathrin, and had obvious characteristics of mesenteric lymph node targeting distribution. Oral administration of BAPC-SME could significantly inhibit the increase in plasma levels of 14 cytokines: TNF-α, IL-6, IFN-γ, MCP-1, IL-17A, IL-27, IL-1α, GM-CSF, MIG, IFN-ß, IL-12, MIP-3α, IL-23, and RANTES in mice experiencing systemic cytokine storm. BAPC-SME could also significantly improve the pathological injury and inflammatory cell infiltration of lung tissue in mice experiencing local cytokine storm. This study does not only provide a new lymphatic targeted drug delivery strategy for the treatment of cytokine storm but also has great practical significance for the clinical development of baicalein self-microemulsion therapies for cytokine storm.

Integration of a hybrid scan approach and in-house high-resolution MS2 spectral database for charactering the multicomponents of Xuebijing Injection

Xuebijing (XBJ) Injection is a reputable patent Chinese medicine widely used to cure sepsis, among the Chinese ″Three Medicines and Three Prescriptions″ solution to fight against COVID-19. We were aimed to achieve the comprehensive multicomponent characterization from the single drugs to traditional Chinese medicine (TCM) formula, by integrating powerful data acquisition and the in-house MS2 spectral database searching. By ultra-high performance liquid chromatography/ion mobility-quadrupole time-of-flight mass spectrometry (UHPLC/IM-QTOF-MS), a hybrid scan approach (HDMSE-HDDDA) was developed, while the HDMSE data for five component drugs and 56 reference compounds were acquired and processed to establish an in-house MS2 spectral database of XBJ. Good resolution of the XBJ components was accomplished on a Zorbax Eclipse Plus C18 column within 24 min, while a fit-for-purpose HDMSE-HDDDA approach was elaborated in two ionization modes for enhanced MS2 data acquisition. XBJ MS2 spectral library was thus established on the UNIFITM platform involving rich structure-related information for the chemicals from five component drugs. We could identify or tentatively characterize 294 components from XBJ, involving 81 flavonoids, 51 terpenoids, 42 phthalides, 40 organic acids, 13 phenylpropanoids, seven phenanthrenequinones, six alkaloids, and 54 others. In contrast to the application of conventional MS1 library, this newly established strategy could demonstrate superiority in the accuracy of identification results and the characterization of isomers, due to the more restricted filtering/matching criteria. Conclusively, the integration of the HDMSE-HDDDA hybrid scan approach and the in-house MS2 spectral database can favor the efficient and more reliable multicomponent characterization from single drugs to the TCM formula.

Reforming global supply chain management under pandemics

The recent outbreak of Coronavirus disease 2019 (COVID-19) has posed serious threats and challenges to global supply chain management (GSCM). To survive the crisis, it is critical to rethink the proper setting of global supply chains and reform many related operational strategies. We hence attempt to reform the GSCM from both supply and demand sides considering different pandemic stages (i.e., pre, during, and post-pandemic stages). In this research paper, we combine a careful literature review with real-world case studies to examine the impacts and specific challenges brought by the pandemic to global supply chains. We first classify the related literature from the demand and supply sides. Based on the insights obtained, we search publicly available information and report real practices of GSCM under COVID-19 in nine top global enterprises. To achieve responsiveness, resilience, and restoration (3Rs), we then propose the "GREAT-3Rs" framework, which shows the critical issues and measures for reforming GSCM under the three pandemic stages. In particular, the "GREAT" part of the framework includes five critical domains, namely, "government proactive policies and measures," "redesigning global supply chains," "economic and financing strategies under risk," "adjustment of operations," and "technology adoption," to help global enterprises to survive the pandemic;"3Rs" are the outputs that can be achieved after using the "GREAT" strategies under the three pandemic stages. Finally, we establish a future research agenda from five aspects.

Government Subsidies and Policies for Mask Production Under COVID-19: Is It Wise to Control Less?

Under the COVID-19 pandemic, governments worldwide have subsidized manufacturers or consumers on the production or purchase of masks. However, the impacts of these subsidies on the mask supply chain (MSC) operations are unclear. Motivated by our interview with a mask manufacturer as well as the observed real-world practices, we establish consumer utility-based stylized models to analytically examine government subsidies and policies in the MSC. We utilize the infection transmission model to capture the social health risk during the COVID-19 outbreak. The government aims to maximize social welfare, which includes the manufacturer's profit, consumer surplus, social health risk, and government subsidy expenditure. Results indicate that when the price is not controlled (i.e., the manufacturer decides it), the manufacturer and consumer subsidy programs are equally efficient in enhancing consumer surplus as well as reducing harm to social health risk under COVID-19. Thus, the government can conduct a subsidy scheme that is easier to implement in practice. However, we surprisingly find that the government's excessive intervention will cause disequilibrium in the MSC. When the price or the manufacturer's dishonest behavior is fully controlled by the government, subsidizing the MSC is not always advisable. Besides, our findings are consistent with the public interest theory;that is, the proper implementation of dishonesty prevention and pricing control policies can improve social welfare but sacrifice consumer surplus. Our results contribute to healthcare operations management and generate managerial insights for MSC management during COVID-19 with industrial validation.

Seeking survivals under COVID‐19: The WhatsApp platform's shopping service operations

Under COVID‐19 outbreak, retail operations are seriously threatened. There are lots of cases in which physical stores basically have to stop operating. This creates problems to the firm, its employees, and consumers. Recently, Timberland in Hong Kong and various other brands such as Joyce Boutiques and The North Face have established the “WhatsApp Shopping Service Operation” (WSO) in which consumers can shop by using the well‐established communication tool “WhatsApp.” Salespeople in stores provide services via WhatsApp to assist the consumers without them having to visit the stores. We collect primary data from real‐world cases and theoretically explore WSO. We build a standard consumer utility based model to derive the firm's optimal pricing and employment decisions under different cases. We evaluate the impacts of COVID‐19 and values of WSO implementation from the “Worker‐Consumer‐Company” (WCC) welfare perspective. Our results interestingly imply that WSO is superior to the traditional online channel in terms of keeping business under the pandemic;meanwhile, implementing WSO can help stimulate demand in the physical store under COVID‐19. However, whether WSO is effective to help increase the firm's profit and WCC welfare depends on both consumer type' distribution and consumers’ fear of infection. When consumers’ fear of infection is very polarized (i.e., extremely low or high), WSO is not recommended. We further propose that the government's subsidy for WSO implementation could be an effective way to help the firm improve its profit and WCC welfare. We also check the robustness of our study by extending the model to consider endogenous consumer type, endogenous service level, and WCC‐welfare‐oriented firm.

Impact of chemotherapy and immunotherapy on the composition and function of immune cells in COVID-19 convalescent with gynecological tumors.

Ongoing pandemic and potential resurgence of Coronavirus disease 2019 (COVID-19) has prompted urgent efforts to investigate the immunological memory of convalescent patients, especially in patients with active cancers. Here we performed single-cell RNA sequencing in peripheral blood samples of 3 healthy donors (HDs), 4 COVID-19 patients (Covs) and 4 COVID-19 patients with active gynecological tumor (TCs) pre- and post- anti-tumor treatment. All Covs patients had recovered from their acute infection. Interestingly, the molecular features of PBMCs in TCs are similar to that in Covs, suggesting that convalescent COVID-19 with gynecologic tumors do not have major immunological changes and may be protected against reinfection similar to COVID-19 patients without tumors. Moreover, the chemotherapy given to these patients mainly caused neutropenia, while having little effect on the proportion and functional phenotype of T and B cells, and T cell clonal expansion. Notably, anti-PD-L1 treatment massively increased cytotoxic scores of NK cells, and T cells, and facilitated clonal expansion of T cells in these patients. It is likely that T cells could protect patients from SARS-CoV-2 virus reinfection and anti-PD-L1 treatment can enhance the anti-viral activity of the T cells.

Seeking survivals under COVID-19: The WhatsApp platform's shopping service operations.

Under COVID-19 outbreak, retail operations are seriously threatened. There are lots of cases in which physical stores basically have to stop operating. This creates problems to the firm, its employees, and consumers. Recently, Timberland in Hong Kong and various other brands such as Joyce Boutiques and The North Face have established the "WhatsApp Shopping Service Operation" (WSO) in which consumers can shop by using the well-established communication tool "WhatsApp." Salespeople in stores provide services via WhatsApp to assist the consumers without them having to visit the stores. We collect primary data from real-world cases and theoretically explore WSO. We build a standard consumer utility based model to derive the firm's optimal pricing and employment decisions under different cases. We evaluate the impacts of COVID-19 and values of WSO implementation from the "Worker-Consumer-Company" (WCC) welfare perspective. Our results interestingly imply that WSO is superior to the traditional online channel in terms of keeping business under the pandemic; meanwhile, implementing WSO can help stimulate demand in the physical store under COVID-19. However, whether WSO is effective to help increase the firm's profit and WCC welfare depends on both consumer type' distribution and consumers' fear of infection. When consumers' fear of infection is very polarized (i.e., extremely low or high), WSO is not recommended. We further propose that the government's subsidy for WSO implementation could be an effective way to help the firm improve its profit and WCC welfare. We also check the robustness of our study by extending the model to consider endogenous consumer type, endogenous service level, and WCC-welfare-oriented firm.